It's happened to all of us. We're making great gains, weights are going up, muscles are getting bigger and stronger-and then we get an injury. Usually it's a soft tissue injury like tendons, ligaments, or cartilage. The muscles could handle the workload but our connective tissue wasn't able to keep up. Everyone knows the mantra that you have to wait at least 48 hours before working the same muscle so you give it time to repair, right? But tendons, ligaments, and cartilage take longer to repair when they're subjected to the same microtrauma that muscle undergoes in a workout. For many people, this results in ongoing unrepaired damage to the tissues that are responsible for delivering the force from the muscles. In addition, breakthrough research has shown that many people are actually in a chronic inflammatory state that upregulates a specific enzyme system that destroys the fibrous structure that makes up the connective tissue. It is this enzyme system that tears down these sinews-sinews that we need to be at their strongest. When this enzyme system, known as matrix metalloproteinases (or MMPs) gets upregulated, we increase the damage to our soft tissues. It is this subtle, ongoing damage that is often responsible for the injuries that derail our progress.1-8
Let's look at this another way. Let's imagine that you've noticed that the walls in your home are showing cracks and that your deck is falling apart. The home inspector tells you that you have a serious termite infestation and something needs to be done. The termites are eating up your support structures. Would you just order some more 2x4s and sheetrock? Of course not-you would start by getting rid of the termites. The MMP enzyme system is like termites to your tendons, ligaments, and cartilage. Sometimes this system is upregulated because of systemic inflammation, sometimes it might be overtraining. It might even be from an old nagging injury that never quite healed right because the termites kept tearing down your body's attempt to repair the damaged area. Regardless of why these enzymes are being over-expressed, they need to be brought into balance so your body can heal properly.
Based on this incredible new scientific research, I've worked with the top researchers that have discovered the most effective way to balance the MMP system and allow the repair process to take place. As a result, we have a great new formula called Sinew Plex that dramatically reduces the over-expression of the MMP enzymes. Sinew Plex has a powerful synergistic combination of nutrients discovered through proteomic research. The results we've already seen have been outstanding! I've had feedback of chronic injuries like knees, elbows, shoulder, and low-back pain all improving in as little as 1 week. We've even heard from one physical therapist who blew out his gastrocnemius that he thought would have to be surgically repaired, but in just 1 week on our new Sinew Plex he was able to put full weight on it without limping or pain. It's not a miracle pill; you should still continue to get your soft-tissue treatments from your chiropractor, massage therapist, or other body-worker. In fact, we had this formula designed specifically to complement these treatments. I recommend it with any soft-tissue injury, whether it's chronic or acute. There is also evidence that prophylactic use may be beneficial to keep your connective tissue at its strongest. You just take 1 tablet with each meal and before each workout to call off the termites and allow your tendons, ligaments, and cartilage to properly repair.9-13
Don't let your joints deteriorate and buy some Sinew Plex today!
References
1. Ravanti L, Kahari VM. Matrix metalloproteinases in wound repair. Int J Mol Med. 2000;6(4):391-407
2. Burrage PS, Mix KS, Brinckerhoff CE. Matrix metalloproteinases: role in arthritis. Front Biosci. 2006;11:529-543
3. Malemud CJ. Matrix metalloproteinases (MMPs) in health and disease; an overview. Front Biosci. 2006;11:1696-1701
4. Takaishi H, Kimura T, Dalal S, Okada Y, D'Armiento J. Joint diseases and matrix metalloproteinases : a role for MMP-13. Curr Pharm Biotechnol. 2008;9(1):47-54
5. Le Maitre CL, Freemont AJ, Hoyland JA. Localisation of deradative enzymes and their inhibitors in the degenerate human invertebral disc. J Pathol. 2004;204(1):47-54
6. Arnoczky SP et al. Matrix metalloproteinases inhibitors prevent a decrease in the mechanical properties of stress-deprived tendons: an in vitro experimental study. Am J Sports Med. 2006;35(5):763-769
7. Riley GP, Curry V, DeGroot J, et al. Matrix metalloproteinase activities and their relationship with collagen remodeling in tendon pathology. Matrix Biol. 2002;21(2):185-195
8. Lo IK et al. Matrix metalloproteinase and tissue inhibitor of matrix metalloproteinases mRNA levels are specifically altered in torn rotator cuff tendons. Am J Sports Med. 2004;32(5):1223-1229.
9. Kuo CL, Chi CW, Liu TY. The anti-inflammatory potential of berberine in vitro and in vivo. Cancer Lett. 2004;203(2):127-137
10. Duan D. et al. Protective effect of niacinamide on interleukin-1beta-induced annulus fibrosus type II collagen degeneration in vitro. J Huazhong Univ Sci Technolog Med Sci. 2007;27(1):68-71
11. Jiang C, Ganther H, Lu J. Monomethyl selenium-specific inhibition of MMP-2 and VEGF expression: implications for angiogenic switch regulation. Mol Carcinog. 2000;29(4)236-250
12. Kuroishi T, Endo Y, Muramoto K, Sugawara S. Biotin deficiency up-regulates TNF-alpha production in murine macrophages. J Leukoc Biol. 2008;83(4):912-920
13. Kahmann L, Uciechowski P, Warmuth S, et al. Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions. Rejuvenation Res. 2008;11(1):227-237